Helen S. Mayberg, M.D., FRCPC

Professor of Psychiatry and Behavioral Sciences and Neurology
Dorothy C. Fuqua Chair of Psychiatric Neuroimaging and Therapeutics

Phone: 404.727.6740
Fax: 404.727.6743

 

Education

1976     BA Psychobiology, UCLA
1981     MD, University of Southern California, School of Medicine
1985     Neurology Resident, Columbia University, Neurological Institute of NY
1987     Nuclear Medicine Fellowship, Johns Hopkins Medical Institutions

Past Positions

1987-91   Instructor & Assistant Professor, Radiology, Neurology, Psychiatry, Johns Hopkins
1991-98   Assistant & Assoc Professor, Neurology, Psychiatry, Radiology UTHSC, San Antonio
1999-03   Professor, Psychiatry & Neurology, Sandra Rotman Chair Neuropsychiatry, U Toronto 


Honors and Awards

2010 President, Society of Biological Psychiatry
2010 Roche Senior Award for Translational Neuroscience
2009 Raymond Adams Award, American Neurological Society
2009 Margaret Pittman Lecturer, NIH, Bethesda, MD
2008 Institute of Medicine, elected member
2008 Centenary Lecturer, University of Toronto
2008 Emil Kraeppelin Professor, Max-Planck Institut fur Psychiatre, Munich, GR
2007 David Seegal AOA Visiting Professorship, Columbia University, NY
2007 Falcone Prize for Mood Disorders Research, NARSAD
2003 Arnold Pfeffer Prize, NY Psychoanalytic Institute (co-recipient, Mario Liotti)
2003 American College of Neuropspychopharmacology (elected member)
2000 American Neurological Association (elected member)
1999 Litchfield Lecturer, Oxford College, England
1999 Sandra Rotman Chair in Neuropsychiatry, University of Toronto
1997 Bexar County Medical Society, 3rd Annual Women in Medicine, Honoree
1996 Gerald Klerman Memorial Award runner-up, NARSAD

Research Focus

My research examines neural systems mediating mood and emotions in health and disease with a primary emphasis on major depression and its recovery.  Functional neuroimaging (PET, fMRI, DTI) serve as the core methodologies, although all projects are multi-disciplinary (clinical trials, neurophysiology, personality structure, genetics, cognitive neuroscience, functional neurosurgery). Defining brain mechanisms underlying major depression and mediating its treatment are the primary goals, with an emphasis on development of algorithms that will discriminate patient subgroups, optimize treatment selection, and provide markers of disease and relapse vulnerability.  These studies further provide foundation for refinement and continued testing of Deep Brain Stimulation (DBS) for treatment resistant depression.   

Grant Support (Active)

Project Title: Imaging Predictors of Treatment Response for Depression
Principal Investigator: Helen Mayberg MD
Funding Source:MH 1R01MH073719-04 NIMH

Project Title: Predictors of Antidepressant Treatment Response: The Emory CIDAR
Principal Investigator: Helen S. Mayberg, MD
Funding Source: P50 MH077083

Project Title: Predictors of treatment response, relapse & recurrence in major depression. 
Principal Investigator: Ed Craighead PhD
Funding Source: 1RO1MH080880-03                 

Project Title: The Emory-MSSM-GSK-NIMH Collaborative Mood and Anxiety Disorders Initiatives
Principle Investigator:  Helen Mayberg, MD
Funding Source: NIMH U19 MH069056

Project Title: Effects of Deep Brain Stimulation on Cingulate and Frontal Oscillations in Treatment Resistant Depression Principal Investigator: Helen Mayberg MD
Funding Source: Dana Foundation

Project Title: Deep Brain Stimulation for Bipolar-2 Treatment Resistant Depression
Principal Investigator: Helen Mayberg, MD
Funding Source: Stanley Medical Research Foundation SMRI#06T-901

Project Title: Deep Brain Stimulation Clinical Research Program for Treatment Resistant Depression (DCRP-TRD)
Principal Investigator: Helen Mayberg, MD
Funding Source: Woodruff Fund

Project Title: Deep Brain Stimulation for Treatment Resistant Depression
Principal Investigator: Helen Mayberg, MD
Funding Source: Dana Foundation

Project Title: Investigating structural-functional brain abnormalities in late life depression
Principle Investigator: Paul Holtzheimer MD (Mayberg, Mentor)
Funding Source: 1K23MH077869

Project Title: Neural Substrates of Depression Risk after Child Abuse
Principal Investigator: Christine Heim, PhD (Mayberg, Mentor)
Funding Source: 1K01 MH073698

Project Title: Functional Neuroanatomy of Recovery from Depression
Principal Investigator: Greg Siegel (University of Pittsburgh)

Funding Source: 1 RO1 MH074807

Publications of Interest: 

  1. Mayberg HS: Limbic-cortical dysregulation: A proposed model of depression. J Neuropsych Clin Neuroscience, 9:471-81, 1997. 
  2. Mayberg HS, Brannan SK, Mahurin R, Jerabek P, Brickman J, Tekell JL, Silva JA, McGinnis S. Cingulate function in depression: A potential predictor of treatment response. NeuroReport, 8:1057-61, 1997.
  3. Mayberg HS, Brannan Sk, Mahurin RK, McGinnin S,. Regional Metabolic Effects of Fluoxetine in Major Depression: Serial Changes and Relationship to Clinical Response. Biol Psychiatry 48:830-843, 2000. 
  4. Goldapple K, Segal Z, Garson C, Lau M, Bieling P, Kennedy S, Mayberg HS.  Modulation of cortical-limbic pathways in major depression: treatment specific effects of CBT. Arch Gen Psych 61:34-41, 2004.    
  5. Fossati P, Hevenor SJ, Lepage M, Graham SJ, Grady C, Keightley ML, Craik F, Mayberg H.  Distributed self in episodic memory: neural correlates of successful retrieval of self-encoded positive and negative personality traits.  Neuroimage. 2004; 4:1596-604.  
  6. Mayberg HS, Lozano A, Voon V, McNeely H, Seminowicz D, Hamani C, Schwalb J, Kennedy S,. Deep Brain Stimulation for Treatment Resistant Depression; Neuron, 2005; 45:651-660. 
  7. Ressler KJ, Mayberg HS.  Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic, Nat NeuroSci 10(9):1116-1124, 2007
  8. Kennedy SH, Konarski J, Segal Z, Lau M, Bieling P, McIntyre R, Mayberg H. Differences in cmrGlc between Responders to CBT & Venlafaxine in a 16-wk Randomized Controlled Trial.  Am J Psych, 164:778-88, 2007.
  9. Farb NA, Segal Z, Mayberg H, Bean J, McKeon D, Anderson A.  Attending to mind and body: Mindfulness training reveals distinct neural modes of self awareness.SCAN 2:313-22, 2007
  10. Lozano AM, Mayberg HS, Hamani C, Giacobbe P, Craddock, RC, Kennedy, SH   Subcallosal cingulate gyrus deep brain stimulation for treatment resistant depression. Biol Psych 64(6): 461-67, 2008. 
  11. McNeely HE, Mayberg HS, Lozano AM, Kennedy SH.  Neuropsychological Impact of Cg25 Deep Brain Stimulation for Treatment Resistant Depression: Preliminary Results over 12 Months, J Nerv Ment Disease, 196:405-410, 2008.
  12. Neimat JS, Hamani C, Giacobbe P, Kennedy SH, Mayberg HS, Lozano AM.  Neural Stimulation successfully treats depression in patient with prior ablative cingulotomy.  Am J Psychiatry, 165: 687-693, 2008
  13. Johansen-Berg H, Gutman D, Behrens T, Matthews P, Rushworth M, Katz E, Lozano A, Mayberg HS. Anatomical connectivity of subgenual cingulate region targeted with DBS for treatment resistant Depression, Cerebral Cortex, 18:1374-83, 2008. 
  14. Gutman, DA, Holtzheimer PE, Behrens TEJ, Johansen-Berg H, Mayberg HS. A Tractography Analysis of Two Deep Brain Stimulation White Matter Targets for Depression.  Biol Psych, 65:276–282, 2009
  15. Palomero-Gallagher, N, Vogt BA, Schleicher A, Mayberg HS, Zilles K.  Receptor architecture of human cingulate cortex: Evaluation of the four-region neurobiological model.  Human Brain Mapping, epub 2008 Nov 25; print  30:2336–55, 2009
  16. Mayberg HS. Targeted Modulation of Neural Circuits: A New Treatment Strategy for Depression. J Clin Investig  119:717-25, 2009.
  17. Konarski JZ, Kennedy SH, Segal ZV, Lau MA, Bieling PJ, McIntyre RS, Mayberg HS.  Predictors of Non-response to CBT or Venlafaxine Using Glucose Metabolism in MDD, J Psych Neurosc,   34:175-180, 2009.
  18. Lemogne C, le Bastard G, Mayberg H, Volle E, Begouignan L, Lehericy S, Allilaire JF, Fossati P.  In Search of the Depressive Self: Medial Frontal Gyrus Convicted by Self-Referential Processing.  SCAN   4(3):305-12, 2009
  19. James GA, Kelley ME, Craddock RC, Holtzheimer PE, Dunlop B, Nemeroff C, Hu XP,* Mayberg HS*.  Exploratory Structural Equation Modeling of Resting-state fMRI: applicability of group models to individual subjects.  NeuroImage,   45(3):778-87, 2009. 
  20. Craddock RC, Holtzheimer PE, Hu XP, Mayberg HS.  Disease state prediction from resting state functional connectivity, Mag Resonance Med   62:1619-28, 2009.
  21. Farb NAS, Anderson A, Mayberg H, Bean J, McKeon D, Segal ZV.  Minding one’s emotions: Mindfulness Training alters neural expression of sadness.  Emotion,   10(1):25-33, 2010.
  22. Craddock RC, James G, Holtzheimer PE, Hu X, Mayberg HS.  A whole brain fMRI atlas generated via spatially constrained spectral clustering.  Human Br Mapping in press 28 Mar 2011
  23. Holtzheimer PE and Mayberg HS.  Stuck in a Rut: rethinking depression and its Treatment.  Trends Neurosci.  34(1):1-9, 2011.  
  24. Hamani C, Mayberg H, Stone S, Laxton A, Haber S, Lozano AM.  The subcallosal cingulate gyrus in the context of major depression.  Biol Psychiatry. 69(4):301-8, 2011
  25. Dunn LB, Holtzheimer PE, Hoop JG, Mayberg HS, Roberts LW, Appelbaum PS.  Ethical Issues in DBS for Treatment-Resistant Depression: Focus on Risk and Consent.  AJOB, 2(1):29-36, 2011.
  26. Kennedy SH, Giacobbe P, Rizi SJ, Placenza FM, Nishikawa Y, Mayberg HS, Lozano AM.  Deep Brain Stimulation for Treatment-Resistant Depression: Follow-up after 3 to 6 years. Am J Psych  168(5):502-10, 2011.
  27. Fins JJ, Mayberg HS, Nuttin B, Kubu CS, Galert T, Sturm V, Stoppenbrink K, Merkel R, Schlaepfer TE.Misuse of the FDA's humanitarian device exemption in deep brain stimulation for obsessive-compulsive disorder. Health Affairs 30(2):302-11, 2011
  28. Fins JJ, Schlaepfer TE, Nuttin B, Kubu CS, Galert T, Sturm V, Merkel R, Mayberg HS. Ethical guidance for the management of conflicts of interest for researchers, engineers and clinicians engaged in the development of therapeutic deep brain stimulation. J Neural Eng. 8(3):033001, 2011.  
  29. Holtzheimer PE, Mayberg HS.  Deep brain stimulation for psychiatric disorders.  Annu Rev Neurosci.  34:289-307, 2011


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