B.S. Louisiana State University, Baton Rouge, LA
M.S. Tulane University, New Orleans, LA
Ph.D. Tulane University, New Orleans, LA (Neuroscience)
DAAD Fellow (1979) University of Kassel, Germany
Postdoctoral Fellow (1981-1983) Emory University, Atlanta, GA
Postdoctoral Fellow (1983-1985) The Johns Hopkins University, Baltimore, MD
1986-1988 Instructor, Neuropathology Laboratory, Dept. of Pathology, Johns Hopkins Medical School, Baltimore, MD
1988-1995 Assistant Professor, Neuropathology Laboratory, Dept. of Pathology, Johns Hopkins Medical School, Baltimore, MD
1995-2002 Director, Alzheimer's Disease Research Program, CNS Pharmacology, Pfizer Global Research and Development-Ann Arbor Laboratories, Ann Arbor, MI
2002-2003 Head, Neuropathology Laboratory, CNS Pharmacology, Pfizer Global Research and Development-Ann Arbor Laboratories, Ann Arbor, MI
2003-present Research Professor, Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, and Associate Professor, Department of Neurology, Emory University, Atlanta, GA
1984-1994 Teaching Assistant, Neuroscience and Dept. of Neurology, Johns Hopkins Medical School
1993-1995 Adjunct Professor, Neurobiology of Aging, Dept. of Psychology, Johns Hopkins University
1994-1995 Visiting Scientist, Dept. of Neurology, University of Greifswald, Germany
1989-present Member, Society for Neuroscience (Councilor, Michigan Neuroscience Chapter, 1995-1997)
2001-present Member, Neurotoxicity Society
2002-present Member, American Association of Neuropathologists
2006-present Scientific Advisor, Alzheimer Research Forum
Kane MD, Lipinski WJ, Callahan, MJ, Bian, F, Durham, RA, Schwarz RD, Roher, AE and Walker LC: Evidence for seeding of b-amyloid by intracerebral infusion of Alzheimer brain extracts in b-amyloid precursor protein-transgenic mice. J. Neurosci. 20: 3606-3611, 2000.
Walker LC and LeVine H: The cerebral proteopathies. Neurobiol. Aging 21: 559-561, 2000.
Callahan MJ, Lipinski WJ, Bian F, Durham RA, Pack A and Walker LC: Augmented senile plaque load in aged female b-amyloid precursor protein transgenic mice. Am. J. Pathol. 158: 1173-1177, 2001.
Bian F, Nath R, Sobocinski G, Booher RN, Lipinski WJ, Callahan MJ, Pack A, Wang KK-W and Walker LC: Axonopathy, tau abnormalities and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice. J. Comp. Neurol. 446: 257-266, 2002.
Walker LC, Callahan MJ, Bian F, Durham RA, Roher AE and Lipinski WJ: Exogenous induction of cerebral b-amyloidosis in bAPP-transgenic mice. Peptides 23: 1241-1247, 2002.
Vogelgesang S, Cascorbi I, Schroeder E, Pahnke J, Kroemer HK, Siegmund W, Kunert-Keil C, Walker LC and Warzok RW: Deposition of Alzheimer’s b-Amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12: 535-541, 2002.
Walker LC, LeVine H, Mattson MP and Jucker M. Inducible proteopathies. Trends Neurosci 29: 438-443, 2006.
Walker L, LeVine H and Jucker M. Koch's postulates and infectious proteins. Acta Neuropathologica 112: 1-4, 2006.
Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J-M, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC and Jucker M. Exogenous induction of cerebral β-amyloidogenesis is governed by agent and host. Science 313: 1781-1784, 2006.
Agca C, Carter S, Fritz JJ, Walker LC, Levey AI, Chan AWS, Lah JJ, and Agca Y. Development of transgenic rats producing human β-Amyloid precursor protein as a model for Alzheimer’s disease; Transgene and endogenous APP genes are regulated tissue-specifically. BMC Neuroscience 9: 28, 2008.
LeVine H III, Walker LC. Molecular polymorphism of Aβ in Alzheimer's disease. Neurobiol. Aging 31: 542-548, 2010 [Epub ahead of print July 2008].
Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson L, Yan Z-X, Roth K, Aguzzi, A, Staufenbiel M, Walker LC and Jucker M. Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation. PNAS 106:12926-12931, 2009.
Rosen RF, Ciliax BJ, Gearing M, Dooyema J, Wingo T, Lah JJ, Ghiso JA, LeVine III H and Walker LC. Deficient High-Affinity Binding of Pittsburgh Compound B in a Case of Alzheimer's disease. Acta Neuropathologica, 119:221-233, 2010.
Rosen RF, Tomidokoro Y, Ghiso JA and Walker LC. SDS-PAGE/immunoblot detection of Abeta multimers in human cortical tissue homogenates using antigen-epitope retrieval. Journal of Visualized Experiments (JoVE) 38: pii: 1916, Apr 23, 2010. PMID: 20418805
Eisele YS, Obermüller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M and Jucker M. Peripherally applied Aβ-containing Inoculates induce cerebral β-amyloidosis. Science 330: 980-982, 2010 PMID: 20966215.
Teipel SJ, Kaza E, Hadlich S, Bauer A, Brüning T, Plath A-S, Krohn M, Scheffler K, Walker LC, Lotze M and Pahnke J. Automated detection of β-amyloid-related cortical and subcortical signal changes in a transgenic model of Alzheimer’s disease using high-field MRI. J Alzheimer’s Dis 23: 221-237, 2011. PMID: 20966552.
Scheffler K, Stenzel J, Krohn M, Lange C, Hofrichter J, Schumacher T, Brüning T, Plath A, Walker L, Pahnke J. Determination of spatial and temporal distribution of microglia by 230nm high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer’s disease. Current Alzheimer Research 8:781-8, 2011. PMID: 20966552.
Rosen RF, Walker LC and LeVine H. PIB binding in aged primate brain: Enrichment of high-affinity sites in humans with Alzheimer’s disease. Neurobiol. Aging 32:223-234, 2011. PMID: 19329226.
Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Brüning T, Plath A-S, Alfen F, Schmidt A, Winter F, Rateitschak K, Wolkenhauer O, Wree A, Gsponer J, Walker LC, Benecke R and Pahnke J. Cerebral amyloid-β proteostasis is highly regulated by the membrane transport protein ABCC1 in mice. J Clin Invest 121:3924-3931, 2011. PMID: 21881209.
Langer F, Eisele YS, Fritschi SK, Staufenbiel M, Walker LC and Jucker M. Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition. J Neurosci 31:14488-14495, 2011. PMID: 21994365.
Jucker M and Walker LC. Pathogenic protein seeding in Alzheimer´s disease and other neurodegenerative disorders. Ann Neurol 70:532-540, 2011. doi: 10.1002/ana.22615. PMID: 22028219.
Rosen RF, Fritz JJ, Dooyema J, Cintron AF, Hamaguchi T, Lah JJ, LeVine III H, Jucker M and Walker LC. Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats. J Neurochem 2011 Oct 21. doi: 10.1111/j.1471-4159.2011.07551.x. [Epub ahead of print]
PMID: 22017494.
Hamaguchi T, Eisele YS, Varvel NH, Lamb BT, Walker LC and Jucker M. The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain. Acta Neuropath 123:31-37, 2012. PMID: 22101366.
Research Interests
Seeded induction of Alzheimer-type pathology; Beta-amyloid and related proteins; Models of Alzheimer's disease; Vascular factors and Alzheimer's disease; Comparative neuropathology of aging